• Laboratory

Biosafety level 3 laboratory, 650 sq. ft. + 75 ft. shower/change room. Negative air flow, pass-through autoclave and ceiling mounted UV lights. Major equipment include an aerosol infection chamber, two 4-ft. class II biosafety cabinets, one 6-ft. class II biosafety cabinet, reach-in and CO₂ incubators, Anoxomat anaerobic environment generating system and Victor 3 microplate multilabel reader.

Biosafety level 2 laboratory, 485 sq. ft. for microbial and cell culture and molecular biology.

Prep/autoclave room, 180 sq. ft. serving both BSL-2 and BSL-3 laboratories.

Medicinal chemistry laboratory, 686 sq. ft. for medicinal and natural products chemistry. Major equipment  includes Shimadzu analytical and semi-prep HPLCs, CEM microwave synthesizer, rotovaps, Biotage solid phase purification system and Shimadzu 2020 LC-MS. NMR spectra are routinely obtained using instruments available in the Department of Medicinal Chemistry and Pharmacognosy (in the College of Pharmacy building) and if need be, through the UIC RRC (see both under Shared Analytical Resources).

ADMET lab, 762 sq. ft. Major equipment includes a Shimadzu 2020 single quadrupole LC-MS, ABI 4000 QTRAP ion trap-triple quadrupole MS with Agilent UPLC, Victor X3 multi-label microplate reader, Spectramax scanning microplate spectrophotometer, (2) biosafety cabinets, CO₂ incubator, 4 ft. chemical fume hood and tissue homogenizer. Eight additional mass spectrometers are available in the RRC Mass Spectrometry Lab (see Shared Analytical Resources below), located one floor above the ITR.

• Animal

The Biological Resources Laboratory at UIC is comprised of 104,000 sq. ft. on three levels. This includes 43 animal rooms for rodents and lagomorphs, each in a suite configuration with its own air handling system. Space is available for projects on an "as needed" basis. The ITR occupies a room with negative air pressure that is only used for infectious agents. It shares a 2^nd room for uninfected mice which are used for tolerance and PK studies. Mice are housed in the Biological Resources Laboratory (BRL). Each floor of the BRL is managed by a team consisting of a Supervisor of Laboratory Animal Care, a board certified Laboratory Animal Veterinarian and a postdoctoral fellow. This management team oversees and works closely with a staff of certified laboratory animal care technicians. Working in collaboration with the investigators and their staff, the BRL staff provides support service for a wide variety of experimental protocols. The UIC Animal Care Program is accredited by the Association for the Assessment and Accreditation of Laboratory Animal Care (AAALAC) and has consistently received positive evaluations from representatives of the Food and Drug Administration, the World Health Organization, the National Institutes of Health and several commercial pharmaceutical and contract laboratories. 

• Shared Analytical Resources

Mass spectrometry: The following LC-MS instruments are available through the UIC Research Resources Center and are located on the 5^th floor of the College of Pharmacy. They are used routinely by ITR personnel in the event that satisfactory results are not obtained using the single quad and trap-triple quad instruments available in the ITR ADMET lab.

In addition, an Agilent GC-triple quadrupole MS is available in the lab of affiliate faculty member, Guido Pauli.

NMR: The Research Resources Center has 360 and 500 MHz instruments available for sample submission and is located across the street in the Medical Sciences Building. The Department of Medicinal Chemistry and Pharmacognosy also maintains two 300 MHz and one 400 MHz instruments on the 5^th floor of the College of Pharmacy. ITR faculty have their academic appointments in this department and therefore are eligible to use these shared instruments. In addition the Center for Structural Biology, located one block from the College of Pharmacy has 600, 800 and 900 MHz NMR available for use.